Mood disorders are common psychiatric conditions that involve persistent disruptions in emotions, affecting almost every aspect of a person’s behaviour. These disorders can lead to increased morbidity and, in severe cases, higher mortality. Among these, depression is particularly prevalent, with around 1 in 5 people experiencing at least one depressive episode during their lifetime.
Standard Approaches to Mood Disorders
Treatment for mood disorders typically begins with nonpharmacological strategies. This includes addressing core lifestyle factors such as:
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Nutrition
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Sleep
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Exercise
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Social triggers
Psychological therapies, ranging from basic counselling to structured cognitive behavioural therapy (CBT) are considered early and effective interventions.
If mood disorders are more severe or unresponsive to lifestyle adjustments and therapy alone, first-line medications are usually prescribed. Selective Serotonin Reuptake Inhibitors (SSRIs), such as Fluoxetine or Sertraline, are commonly used. While these medications target brain chemistry, it is always recommended they are combined with psychological therapy to support changes in brain pathways and overall emotional wellbeing.
When Standard Treatments Are Not Enough
For some patients, standard treatments may be ineffective or cause unwanted side effects. In these cases, alternative therapies, including cannabis-based medicinal products (CBMPs), is an option. Research suggests that CBMPs can help reduce depressive symptoms in some individuals.
A study by Mangoo et al. (2022) examined clinical outcomes of medicinal cannabis therapy for depression using data from the UK Medical Cannabis Registry. Results showed that patients experienced reduced depression severity at 1, 3, and 6 months, measured by the Patient Health Questionnaire 9 (PHQ-9).
These findings highlight the potential role of medical cannabis as a complementary treatment for mood disorders, particularly for those who do not respond to conventional therapies.
Conclusion
Mood disorders like depression are complex and affect millions of people worldwide. Standard approaches—psychological therapy, lifestyle adjustments, and SSRIs—remain first-line treatments. For patients who require alternative solutions, cannabis-based medicinal products could offer additional support under the guidance of specialist clinicians.
References
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Mangoo et al. 2022. “Assessment of clinical outcomes of medicinal cannabis therapy for depression: analysis from the UK Medical Cannabis Registry.” Expert Rev Neurother. Nov-Dec.
